2-氨基-5-硝基苯甲酸合成路线 （共 87 条）
反应条件
1: aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 4 h 2: aq. HCl / 1 h View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1: 10 h / 150 °C 2: phosphorus pentachloride; trichlorophosphate / 6.5 h / Reflux View Scheme
参考文献
Zhu, Lina; Jin, Jing; Liu, Chang; Zhang, Chongjing; Sun, Yan; Guo, Yanshen; Fu, Decai; Chen, Xiaoguang; Xu, Bailing
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 9 p. 2797 - 2807
参考文献
Tsuda; Oguri
Yakugaku Zasshi, 1942 , vol. 62, p. 66,68; dtsch. Ref. S. 24
Chem.Abstr., 1951 , p. 1580
反应条件
1: 200 °C 2: SnCl2; water; HCl View Scheme
参考文献
Tsuda; Oguri
Yakugaku Zasshi, 1942 , vol. 62, p. 66,68; dtsch. Ref. S. 24
Chem.Abstr., 1951 , p. 1580
反应条件
Behandeln des Reaktionsproduktes mit Wasser;
参考文献
Spring; Woods
Journal of the Chemical Society, 1945 , p. 625,627
Full Text Show Details
Niyogy
Journal of the Indian Chemical Society, 1931 , vol. 8, p. 59,65
反应条件
in tetrahydrofuran; toluene T=20°C; 0.5 h;
参考文献
Ursuegui; Chivot; Moutin; Burr; Fossey; Cailly; Laayoun; Fabis; Laurent
Chemical Communications, 2014 , vol. 50, # 43 p. 5748 - 5751
反应条件
copper(l) iodide; potassium carbonate; L-proline in water; N,N-dimethyl-formamide T=160°C; 1 h; Microwave irradiation;
参考文献
Marques, Emerson F.; Bueno, Mauro A.; Duarte, Patricia D.; Silva, Larissa R.S.P.; Martinelli, Ariani M.; Dos Santos, Caio Y.; Severino, Richele P.; Broemme, Dieter; Vieira, Paulo C.; Correa, Arlene G.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 10 - 21
参考文献
Hoffmann-La Roche Inc.
Patent: US5688803 A1, 1997 ;
反应条件
1: 80 percent / thionyl chloride; DMF 2: propan-2-ol / Heating 3: hydrazine monohydrate / Raney Ni / ethanol; H2O; propan-2-ol View Scheme
参考文献
THE SCRIPPS RESEARCH INSTITUTE; CARROLL, Kate, S.
Patent: WO2014/89546 A1, 2014 ;
反应条件
ammonia; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in water; N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
