2-氨基-5-硝基苯甲酸合成路线 （共 87 条）
反应条件
1: 80 percent / thionyl chloride; DMF View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1: 87 percent / 0.67 h / 150 °C / microwave irradiation 2: 90 percent / ammonium formate / Pd/C / methanol / 0.17 h / 65 °C / microwave irradiation View Scheme
参考文献
Kulkarni, Shridhar S.; Singh, Satyakam; Shah, Janki R.; Low, Woon-Kai; Talele, Tanaji T.
European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 264 - 273
反应条件
1: 80 percent / thionyl chloride; DMF 2: propan-2-ol / Heating View Scheme
参考文献
THE SCRIPPS RESEARCH INSTITUTE; CARROLL, Kate, S.
Patent: WO2014/89546 A1, 2014 ;
反应条件
1: aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 4 h
2: aq. HCl / 1 h
3: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
4: 373 mg / triethylamine / propan-2-ol / 2 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 4 h
2: aq. HCl / 1 h
3: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
4: triethylamine / propan-2-ol / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 4 h
2: aq. HCl / 1 h
3: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
4: triethylamine / propan-2-ol / 20 °C
5: 84 percent / aq. NaOH / ethanol / 2 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 4 h
2: aq. HCl / 1 h
3: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
4: triethylamine / propan-2-ol / 20 °C
5: 84 percent / aq. NaOH / ethanol / 2 h / 20 °C
6: 91 percent / aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 0 - 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: aqueous ammonia; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 4 h
2: aq. HCl / 1 h
3: thionyl chloride; N,N-dimethylformamide / 3 h / Heating
4: triethylamine / propan-2-ol / 20 °C
5: 84 percent / aq. NaOH / ethanol / 2 h / 20 °C
6: 1-hydroxybenzotriazole; 1-ethyl-3-[(dimethylamino)propyl]carbodiimide / dimethylformamide; H2O / 0 - 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3869 - 3878
反应条件
1: copper(l) iodide; potassium carbonate; L-proline / water; N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation
2: trichlorophosphate / 2 h / Inert atmosphere; Reflux
3: hydrogenchloride / ethanol; water / 1 h / Reflux
View Scheme
参考文献
Marques, Emerson F.; Bueno, Mauro A.; Duarte, Patricia D.; Silva, Larissa R.S.P.; Martinelli, Ariani M.; Dos Santos, Caio Y.; Severino, Richele P.; Broemme, Dieter; Vieira, Paulo C.; Correa, Arlene G.
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 10 - 21
反应条件
1: 80 percent / thionyl chloride; DMF
2: propan-2-ol / Heating
View Scheme
参考文献
Mishani, Eyal; Abourbeh, Galith; Jacobson, Orit; Dissoki, Samar; Ben Daniel, Revital; Rozen, Yulia; Shaul, Mazal; Levitzki, Alexander
Journal of Medicinal Chemistry, 2005 , vol. 48, # 16 p. 5337 - 5348
