2-氨基-5-硝基苯甲酸合成路线 （共 87 条）
反应条件
(i) aq. NaOH, (ii) /BRN= 385653/, (iii) AcCl; Multistep reaction;
参考文献
Naik; Amin; Patel
Journal of the Indian Chemical Society, 1979 , vol. 56, # 7 p. 708 - 711
反应条件
1: Behandeln des Reaktionsproduktes mit Wasser
2: acetic acid; zinc
View Scheme
参考文献
Pertsch
Patent: DE133679 ;
反应条件
hydrogenchloride; sodium azide; sodium acetate; sodium nitrite
1.) water, <5 deg C; Yield given. Multistep reaction;
参考文献
Ardakani, Manouchehr Azadi; Smalley, Robert K.; Smith, Richard H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2501 - 2506
反应条件
1: PhCOCl, Py
2: H2 / Raney-Ni / dioxane
View Scheme
参考文献
Errede,L.A. et al.
Journal of Organic Chemistry, 1977 , vol. 42, p. 12 - 18
反应条件
1: 88 percent / HOBt; EDC*HCl; ammonia / dimethylformamide; H2O / 1 h / 20 °C
2: 89 percent / conc. HCl / 1.5 h / 20 °C
3: SOCl2; DMF / 3 h / Heating
4: 403 mg / Et3N / propan-2-ol / 1 h / 20 °C
View Scheme
参考文献
Tobe, Masanori; Isobe, Yoshiaki; Tomizawa, Hideyuki; Nagasaki, Takahiro; Takahashi, Hirotada; Fukazawa, Tominaga; Hayashi, Hideya
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 3 p. 383 - 391
反应条件
1: borane-THF / tetrahydrofuran / 23 h / 0 - 30 °C / |Inert atmosphere
2: manganese(IV) oxide / dichloromethane / 23 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 19 p. 5810 - 5831
参考文献
Griess
Chemische Berichte, 1878 , vol. 11, p. 1734
Chemische Berichte, 1887 , vol. 20, p. 407
