pyridine; trichlorophosphate in carbon disulfide 4 h;

1: 1) Mg / Et2O, 2) 30 min 2: 69 percent / POCl3 / pyridine / CS2 / 4 h View Scheme

1: 1) Mg / Et2O, 2) 30 min 2: 69 percent / POCl3 / pyridine / CS2 / 4 h View Scheme

1.1: NEt3 2.1: MCPBA / CHCl3 / 1 h / 0 °C 3.1: BuLi; HMPA / tetrahydrofuran / 0.17 h / -78 °C 3.2: 95 percent / tetrahydrofuran / -78 °C 4.1: 60 percent / (COCl)2; TMP / CH2Cl2 / -50 °C View Scheme

1.1: MCPBA / CHCl3 / 1 h / 0 °C 2.1: BuLi; HMPA / tetrahydrofuran / 0.17 h / -78 °C 2.2: 95 percent / tetrahydrofuran / -78 °C 3.1: 60 percent / (COCl)2; TMP / CH2Cl2 / -50 °C View Scheme

1.1: BOP-DIPEA / dimethylformamide / 1 h / 20 °C 2.1: MCPBA / CHCl3 / 1 h / 0 °C 3.1: BuLi; HMPA / tetrahydrofuran / 0.17 h / -78 °C 3.2: 95 percent / tetrahydrofuran / -78 °C 4.1: 60 percent / (COCl)2; TMP / CH2Cl2 / -50 °C View Scheme

1.1: BuLi; HMPA / tetrahydrofuran / 0.17 h / -78 °C 1.2: 95 percent / tetrahydrofuran / -78 °C 2.1: 60 percent / (COCl)2; TMP / CH2Cl2 / -50 °C View Scheme

1.1: 3-chloro-benzenecarboperoxoic acid / chloroform / 0.83 h / 0 °C 2.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere 3.1: 2,4,6-trimethyl-pyridine; oxalyl dichloride / dichloromethane / -50 °C / Inert atmosphere View Scheme

1.1: n-butyllithium / tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane / 0.17 h / -70 °C / Inert atmosphere 1.2: -78 °C / Inert atmosphere 2.1: 2,4,6-trimethyl-pyridine; oxalyl dichloride / dichloromethane / -50 °C / Inert atmosphere View Scheme