2-甲氧基-6-甲基苯甲酸合成路线 （共 45 条）
反应条件
1.1: thionyl chloride / 8 h / 20 °C
2.1: triethylamine / CH2Cl2 / 0 - 20 °C
2.2: 3.80 g / methanesulfonyl chloride / CH2Cl2 / 0 - 20 °C
3.1: sec-butyllithium / diethyl ether; hexane; cyclohexane / 1 h / -78 °C
3.2: diethyl ether; hexane; cyclohexane / -78 - 20 °C
4.1: silica gel / CH2Cl2 / 96 h / 30 °C
4.2: LiCl / dimethylformamide / 17 h / 150 °C
5.1: 100 percent / aq. HCl / methanol / 3 h / 20 °C
View Scheme
参考文献
Uchida, Katsuya; Fukuda, Tsutomu; Iwao, Masatomo
Tetrahedron, 2007 , vol. 63, # 30 p. 7178 - 7186
反应条件
1: 30 percent / conc. H2SO4 / 1,2-dichloro-ethane / 6 h / Heating
2: 57 percent / NBS, benzoyl peroxide / CCl4 / 6 h / Heating; Irradiation
3: CaCO3 / ethanol; H2O / Heating
View Scheme
参考文献
Islam, Md. Rabiul; Joule, John A.
Journal of Chemical Research, Miniprint, 1991 , # 2 p. 367 - 378
反应条件
1: 95 percent
2: 96 percent
View Scheme
参考文献
Matsuda, Fuyuhiko; Kawasaki, Motoji; Ohsaki, Masako; Yamada, Kaoru; Terashima, Shiro
Tetrahedron, 1988 , vol. 44, # 18 p. 5745 - 5760
反应条件
thionyl chloride
4 h; Heating;
参考文献
Islam, Md. Rabiul; Joule, John A.
Journal of Chemical Research, Miniprint, 1991 , # 2 p. 367 - 378
反应条件
1: 70 percent / bromine / acetic acid / 2.5 h
2: thionyl chloride / DMF / Heating
3: 0.5 g / 550 °C / 0.02 Torr
View Scheme
参考文献
Barve; Schiess
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004 , vol. 43, # 8 p. 1729 - 1736
