3-[4-[2-[(5-氯-2-甲氧基-苯甲酰基)氨基]乙基]苯基]丙酸合成路线 （共 7 条）
反应条件
water; lithium hydroxide hydrate in tetrahydrofuran
T=0 - 20°C;
参考文献
Kabro, Anzhelika; Lachance, Hugo; Marcoux-Archambault, Iris; Perrier, Valerie; Dore, Vicky; Gros, Christina; Masson, Veronique; Gregoire, Jean-Marc; Ausseil, Frederic; Cheishvili, David; Laulan, Nathalie Bibens; St-Pierre, Yves; Szyf, Moshe; Arimondo, Paola B.; Gagnon, Alexandre
MedChemComm, 2013 , vol. 4, # 12 p. 1562 - 1570
反应条件
hydrogen; palladium on barium sulfate
参考文献
Boehringer Mannheim
Patent: DE2517229 , 1976 ;
Chem.Abstr., 1977 , vol. 86, # 55168
反应条件
1: Py, piperidine
2: H2 / Pd-BaSO4
View Scheme
参考文献
Boehringer Mannheim
Patent: DE2517229 , 1976 ;
Chem.Abstr., 1977 , vol. 86, # 55168
反应条件
1: triethylamine / isopropyl alcohol / 2 h / 20 °C / |Inert atmosphere
2: triethylamine; Pd(PPh3)2Cl2; lithium chloride / N,N-dimethyl-formamide / 3 h / 130 °C / |Inert atmosphere; |Microwave irradiation; |Sealed tube
3: hydrogen; palladium 10 on activated carbon / methanol / 3 h / 20 °C
4: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
5: triethylamine / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
6: lithium hydroxide hydrate; water / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Kabro, Anzhelika; Lachance, Hugo; Marcoux-Archambault, Iris; Perrier, Valerie; Dore, Vicky; Gros, Christina; Masson, Veronique; Gregoire, Jean-Marc; Ausseil, Frederic; Cheishvili, David; Laulan, Nathalie Bibens; St-Pierre, Yves; Szyf, Moshe; Arimondo, Paola B.; Gagnon, Alexandre
MedChemComm, 2013 , vol. 4, # 12 p. 1562 - 1570
反应条件
1: triethylamine / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
2: lithium hydroxide hydrate; water / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Kabro, Anzhelika; Lachance, Hugo; Marcoux-Archambault, Iris; Perrier, Valerie; Dore, Vicky; Gros, Christina; Masson, Veronique; Gregoire, Jean-Marc; Ausseil, Frederic; Cheishvili, David; Laulan, Nathalie Bibens; St-Pierre, Yves; Szyf, Moshe; Arimondo, Paola B.; Gagnon, Alexandre
MedChemComm, 2013 , vol. 4, # 12 p. 1562 - 1570
反应条件
1: triethylamine; Pd(PPh3)2Cl2; lithium chloride / N,N-dimethyl-formamide / 3 h / 130 °C / |Inert atmosphere; |Microwave irradiation; |Sealed tube
2: hydrogen; palladium 10 on activated carbon / methanol / 3 h / 20 °C
3: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
4: triethylamine / dichloromethane / 3 h / 0 - 20 °C / |Inert atmosphere
5: lithium hydroxide hydrate; water / tetrahydrofuran / 0 - 20 °C
View Scheme
参考文献
Kabro, Anzhelika; Lachance, Hugo; Marcoux-Archambault, Iris; Perrier, Valerie; Dore, Vicky; Gros, Christina; Masson, Veronique; Gregoire, Jean-Marc; Ausseil, Frederic; Cheishvili, David; Laulan, Nathalie Bibens; St-Pierre, Yves; Szyf, Moshe; Arimondo, Paola B.; Gagnon, Alexandre
MedChemComm, 2013 , vol. 4, # 12 p. 1562 - 1570
参考文献
Boehringer MA
Patent: DD124974DE2604560 , 19771977 ;
Chem.Abstr., 1977 , vol. 87, # 167763
