1,4-二甲氧基-2-甲基硫代苯合成路线 （共 9 条）
反应条件
1: N-methyl-N-formyl-aniline With trichlorophosphate
T=40 - 50°C; Vilsmeier reaction;
2: 1,4-dimethoxy-2-methylthiobenzene T=70°C; 0.25 h;
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
1.1: 99 percent / Zn; aq. HCl
2.1: KOH / methanol / 1 h
2.2: 99 percent / methanol / 0.5 h / Heating
3.1: POCl3 / 40 - 50 °C
3.2: 73 percent / 0.25 h / 70 °C
View Scheme
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
1.1: 68.3 percent / aq. HOSO2Cl
2.1: 99 percent / Zn; aq. HCl
3.1: KOH / methanol / 1 h
3.2: 99 percent / methanol / 0.5 h / Heating
4.1: POCl3 / 40 - 50 °C
4.2: 73 percent / 0.25 h / 70 °C
View Scheme
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
1.1: KOH / methanol / 1 h
1.2: 99 percent / methanol / 0.5 h / Heating
2.1: POCl3 / 40 - 50 °C
2.2: 73 percent / 0.25 h / 70 °C
View Scheme
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
反应条件
sodium hydride
1.) DMF, ice-bath, 2.) room temperature; Yield given. Multistep reaction;
参考文献
Schwartz, John A.
Synthetic Communications, 1986 , vol. 16, # 5 p. 565 - 570
反应条件
(i) SnCl4, CH2Cl2, (ii) H2O; Multistep reaction;
参考文献
Nichols; Shulgin
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 10 p. 1554 - 1556
反应条件
ammonium acetate
Heating;
参考文献
Gallardo-Godoy, Alejandra; Fierro, Angelica; McLean, Thomas H.; Castillo, Mariano; Cassels, Bruce K.; Reyes-Parada, Miguel; Nichols, David E.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2407 - 2419
参考文献
Nichols; Shulgin
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 10 p. 1554 - 1556
反应条件
1: NH4OAc
2: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Nichols; Shulgin
Journal of Pharmaceutical Sciences, 1976 , vol. 65, # 10 p. 1554 - 1556
