5-乙炔基-1-甲基-1H-吲哚合成路线 （共 5 条）
反应条件
1: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in dichloromethane
Sonogashira Coupling; 3 h;
2: With sodium hydroxide in tetrahydrofuran; methanol
T=20°C;
参考文献
BIONOMICS LIMITED
Patent: WO2008/70908 A1, 2008 ;
Location in patent: Page/Page column 55; 56 ;
反应条件
1: (Bromomethyl)triphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran
T=-78°C; 0.5 h;
2: N-methyl-1H-indole-5-carbaldehyde in tetrahydrofuran
T=-78 - 20°C;
参考文献
Dalgleish, Simon; Labram, John G.; Li, Zhe; Wang, Jianpu; McNeill, Christopher R.; Anthopoulos, Thomas D.; Greenham, Neil C.; Robertson, Neil
Journal of Materials Chemistry, 2011 , vol. 21, # 39 p. 15422 - 15430
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran
0.25 h;
参考文献
Flynn, Bernard L.; Gill, Gurmit S.; Grobelny, Damian W.; Chaplin, Jason H.; Paul, Dharam; Leske, Annabell F.; Lavranos, Tina C.; Chalmers, David K.; Charman, Susan A.; Kostewicz, Edmund; Shackleford, David M.; Morizzi, Julia; Hamel, Ernest; Jung, M. Katherine; Kremmidiotis, Gabriel
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 6014 - 6027
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 1 h / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.25 h
View Scheme
参考文献
Flynn, Bernard L.; Gill, Gurmit S.; Grobelny, Damian W.; Chaplin, Jason H.; Paul, Dharam; Leske, Annabell F.; Lavranos, Tina C.; Chalmers, David K.; Charman, Susan A.; Kostewicz, Edmund; Shackleford, David M.; Morizzi, Julia; Hamel, Ernest; Jung, M. Katherine; Kremmidiotis, Gabriel
Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 6014 - 6027
反应条件
copper(l) chloride in 1,4-dioxane
参考文献
Kotlyarevskii,I.L.; Pavlyukhina,L.A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1976 , vol. 25, p. 2206 - 2207
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1976 , vol. 25, # 10 p. 2363 - 2364
