1: 2-bromo-9,9-dioctyl-9H-fluorene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 2: 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane in tetrahydrofuran; hexane T=20°C; Substitution; 24 h; Further stages.;
tert.-butyl lithium in tetrahydrofuran T=-78°C; 1 h;
参考文献
Park, Young-Il; Lee, Joong Suk; Kim, Beom Joon; Kim, Beomjin; Lee, Jaehyun; Kim, Do Hwan; Oh, Se-Young; Cho, Jeong Ho; Park, Jong-Wook
Chemistry of Materials, 2011 , vol. 23, # 17 p. 4038 - 4044
1: With n-butyllithium in tetrahydrofuran; hexane T=-70 - -40°C; Inert atmosphere; 2: With hydrogenchloride in tetrahydrofuran; hexane; water T=0°C; pH=3;
参考文献
SMITH KLINE BEECHAM CORPORATION
Patent: WO2009/32653 A1, 2009 ;
Location in patent: Page/Page column 10; 40 ;
WO 2009/032653 A1
n-butyllithium in tetrahydrofuran; hexane T=-60°C; Flow reactor;
参考文献
Newby, James A.; Huck, Lena; Blaylock, D. Wayne; Witt, Paul M.; Ley, Steven V.; Browne, Duncan L.
Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 263 - 271
n-butyllithium; tri-isopropoxy-borane in tetrahydrofuran; hexane T=-60°C;
参考文献
Newby, James A.; Huck, Lena; Blaylock, D. Wayne; Witt, Paul M.; Ley, Steven V.; Browne, Duncan L.
Chemistry - A European Journal, 2014 , vol. 20, # 1 p. 263 - 271
