(S)-(+)-2-辛醇合成路线 （共 200 条）
反应条件
cytochrome P450 BM-3_A74G F87V L188Q T=37°C; pH=7.5; 22 h; aq. bufferEnzymatic reaction; optical yield given as percent eestereoselective reaction;
参考文献
Wu, Li-Lan; Yang, Chung-Ling; Lo, Feng-Chun; Chiang, Chih-Hsiang; Chang, Chun-Wei; Ng, Kok Yaoh; Chou, Ho-Hsuan; Hung, Huei-Ying; Chan, Sunney I.; Yu, Steve S.-F.
Chemistry - A European Journal, 2011 , vol. 17, # 17 p. 4774 - 4787
反应条件
T=100°C; bei 8-taegigem Erhitzen im Kohlendioxydstrom;
参考文献
Journal of the American Chemical Society, , vol. 71, p. 226
反应条件
barium dihydroxide; methanesulfonic acid 1.) MeOH, reflux, 16h, 2.) reflux, 4h; Yield given. Multistep reaction;
参考文献
Angewandte Chemie, , vol. 102, # 12 p. 1457 - 1459
反应条件
1,4-dioxane; titanium(IV) isopropylate; bis{(4R,5R)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanolato-O,O'}titanium(IV); zinc(II) chloride 1a.) Et2O, r.t., 2 h, 1b.) 45 min, 2a.) -78 deg C, 1 h, 2b) -30 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 48, # 27 p. 5719 - 5730
参考文献
Journal of the Chemical Society, , p. 2513
反应条件
dipotassium hydrogenphosphate; phosphoric acid; EC 1.1.1.2 ketoreductase in hexane T=25°C; pH=7.3; 168 h; Equilibrium constant; Further Variations:Solvents;
参考文献
Journal of Chemical Thermodynamics, , vol. 37, # 1 p. 89 - 96
反应条件
2: 1.) sec-BuLi, (-)-Spartein / 1.) Cyclohexan, Isopentan, Ether, -78 deg C, 2.) -78 deg C, 16h 3: 1.) Methansulfonsaeure, 2.) Ba(OH)2*8H2O / 1.) MeOH, reflux, 16h, 2.) reflux, 4h View Scheme
参考文献
Angewandte Chemie, , vol. 102, # 12 p. 1457 - 1459
反应条件
1: 1.) sec-BuLi, (-)-Spartein / 1.) Cyclohexan, Isopentan, Ether, -78 deg C, 2.) -78 deg C, 16h 2: 1.) Methansulfonsaeure, 2.) Ba(OH)2*8H2O / 1.) MeOH, reflux, 16h, 2.) reflux, 4h View Scheme
参考文献
Angewandte Chemie, , vol. 102, # 12 p. 1457 - 1459
反应条件
2: 1.) sec-BuLi, (-)-Spartein / 1.) Cyclohexan, Isopentan, Ether, -78 deg C, 2.) -78 deg C, 16h 3: 1.) Methansulfonsaeure, 2.) Ba(OH)2*8H2O / 1.) MeOH, reflux, 16h, 2.) reflux, 4h View Scheme
参考文献
Angewandte Chemie, , vol. 102, # 12 p. 1457 - 1459
反应条件
1: With sec-alkylsulfatase Pisa1 in dimethyl sulfoxide T=30°C; 6 h; aq. bufferEnzymatic reaction; 2: With toluene-4-sulfonic acid in 1,4-dioxane; tert-butyl methyl ether; water Kinetics; Temperature; optical yield given as percent ee;
参考文献
Advanced Synthesis and Catalysis, , vol. 354, # 9 p. 1737 - 1742
