5-氯-2-甲氧基-4-甲氨基苯甲酸合成路线 （共 8 条）
反应条件
sodium hydroxide T=80°C;
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 10 p. 1224 - 1230
反应条件
1: 93 percent / chlorine / CHCl3 / 3 - 10 °C 2: concd. sulfuric acid / 50 °C 3: 3.7percent aq. sodium hydroxide / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 10 p. 1224 - 1230
反应条件
1: 67 percent / KOH / acetone / 2 h / Heating 2: NCS / dimethylformamide / 80 °C 3: conc. H2SO4 / 1.5 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 50, # 7 p. 941 - 959
反应条件
1: NCS / dimethylformamide / 80 °C 2: conc. H2SO4 / 1.5 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 50, # 7 p. 941 - 959
反应条件
1: concd. sulfuric acid / 50 °C 2: 3.7percent aq. sodium hydroxide / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 10 p. 1224 - 1230
反应条件
sulfuric acid 1.5 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 50, # 7 p. 941 - 959
反应条件
1: triethylamine / CH2Cl2 / 0.5 h / -40 - -10 °C
2: CH2Cl2 / 2 h / Ambient temperature
View Scheme
参考文献
Iwanami; Takashima; Hirata; Hasegawa; Usuda
Journal of Medicinal Chemistry, 1981 , vol. 24, # 10 p. 1224 - 1230
参考文献
Yamanouchi Pharmaceutical Co., Ltd.
Patent: US4197243 A1, 1980 ;
