N-(2-甲基苯基)-2-甲基苯胺合成路线 （共 26 条）
参考文献
Battegay; Silberman; Fischer
Chim.et Ind.Sonderband 11.Congr.Chim.ind. Paris 1931 S.525
反应条件
palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; sodium t-butanolate in toluene
T=100°C; Neutral conditions;
参考文献
NITTO DENKO CORPORATION; ZHENG, Shijun
Patent: WO2014/93353 A1, 2014 ;
Location in patent: Paragraph 129 ;
反应条件
lithium amide; (CyPF-t-Bu)PdCl2 in ethylene glycol dimethyl ether
T=80°C; 24 h;
参考文献
YALE UNIVERSITY
Patent: WO2007/109365 A2, 2007 ;
Location in patent: Page/Page column 48-49; 50 ;
反应条件
caesium carbonate; urea; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in 1,4-dioxane
T=100°C; 36 h;
参考文献
Sergeev; Artamkina; Beletskaya
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 12 p. 1741 - 1752
反应条件
1: With ammonia; sodium t-butanolate; [(CyPF-tBu)PdCl2] in ethylene glycol dimethyl ether
T=90°C; P=4137.29 - 10343.2 Torr; 24 h;
2: With hydrogenchloride in ethylene glycol dimethyl ether; water
T=20°C; 0.0833333 h;
3: in ethylene glycol dimethyl ether; water
Product distribution / selectivity;
参考文献
YALE UNIVERSITY
Patent: WO2007/109365 A2, 2007 ;
Location in patent: Page/Page column 48-49; 51 ;
反应条件
potassium carbonate in water
T=20°C; 5 h;
参考文献
Nasrollahzadeh, Mahmoud; Azarian, Abbas; Ehsani, Ali; Zahraei, Ali
Tetrahedron Letters, 2014 , vol. 55, # 17 p. 2813 - 2817
反应条件
1: With lithium amide; [(CyPF-tBu)PdCl2] in ethylene glycol dimethyl ether
T=80°C; 24 h; Sealed vial;
2: With hydrogenchloride in ethylene glycol dimethyl ether; water
T=20°C; 0.0833333 h;
3: With sodium hydrogencarbonate in ethylene glycol dimethyl ether; water
Product distribution / selectivity;
参考文献
YALE UNIVERSITY
Patent: WO2007/109365 A2, 2007 ;
Location in patent: Page/Page column 48-49; 51 ;
反应条件
lithium amide; tris(dibenzylideneacetone)dipalladium (0); biphenyl-2-yl-di-tert-butyl-phosphane; sodium t-butanolate in toluene
T=80°C; 19 h;
参考文献
Huang; Buchwald
Organic letters, 2001 , vol. 3, # 21 p. 3417 - 3419
反应条件
Pd[P(o-tol)3]2; CyPF-t-Bu; ammonia; sodium t-butanolate in 1,4-dioxane
T=50°C; 24 h; Inert atmosphere;
参考文献
Vo, Giang D.; Hartwig, John F.
Journal of the American Chemical Society, 2009 , vol. 131, # 31 p. 11049 - 11061
反应条件
(2-phenyl-1H-inden-3-yl)-dicyclohexylphosphinium tetrafluoroborate; bis(dibenzylideneacetone)-palladium(0); sodium t-butanolate in ethylene glycol dimethyl ether
T=20 - 120°C; Buchwald-Hartwig amination; Inert atmosphere;
参考文献
Chen, Lei; Yu, Guang-Ao; Li, Fang; Zhu, Xiaolei; Zhang, Bei; Guo, Rui; Li, Xiaozhi; Yang, Qihua; Jin, Shan; Liu, Chenchen; Liu, Sheng-Hua
Journal of Organometallic Chemistry, 2010 , vol. 695, # 14 p. 1768 - 1775
