(2E)-2-甲基-3-(4-甲基苯基)-2-丁烯酸合成路线 （共 7 条）
反应条件
lithium hydroxide hydrate; water in tetrahydrofuran; methanol
T=20 - 70°C;
参考文献
Jolit, Anais; Walleser, Patrick M.; Yap, Glenn P. A.; Tius, Marcus A.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 24 p. 6180 - 6183
Angew. Chem., 2014 , vol. 126, # 24 p. 6294 - 6297
反应条件
1.1: sodium hydride / mineral oil; toluene / 1.5 h / 85 °C
1.2: 2 h / 0 °C
2.1: copper (I) cyanide / diethyl ether / 0.5 h / -50 °C / |Inert atmosphere
2.2: 0.5 h / -50 °C / |Inert atmosphere
3.1: lithium hydroxide hydrate; water / tetrahydrofuran; methanol / 20 - 70 °C
View Scheme
参考文献
Jolit, Anais; Walleser, Patrick M.; Yap, Glenn P. A.; Tius, Marcus A.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 24 p. 6180 - 6183
Angew. Chem., 2014 , vol. 126, # 24 p. 6294 - 6297
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 60 °C / |Inert atmosphere
2.1: sodium hydride / mineral oil; toluene / 1.5 h / 85 °C
2.2: 2 h / 0 °C
3.1: copper (I) cyanide / diethyl ether / 0.5 h / -50 °C / |Inert atmosphere
3.2: 0.5 h / -50 °C / |Inert atmosphere
4.1: lithium hydroxide hydrate; water / tetrahydrofuran; methanol / 20 - 70 °C
View Scheme
参考文献
Jolit, Anais; Walleser, Patrick M.; Yap, Glenn P. A.; Tius, Marcus A.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 24 p. 6180 - 6183
Angew. Chem., 2014 , vol. 126, # 24 p. 6294 - 6297
反应条件
potassium hydroxide in 1,4-dioxane; water
24 h; Heating; Yield given. Yields of byproduct given;
参考文献
Balsamo, Aldo; Crotti, Paolo; Macchia, Bruno; Macchia, Franco; Martinelli, Adriano; et al.
Gazzetta Chimica Italiana, 1980 , vol. 110, # 5/6 p. 327 - 332
参考文献
Rupe; Steiger; Fiedler
Chemische Berichte, 1914 , vol. 47, p. 67
反应条件
in ethanol
80 h; Irradiation; Yield given;
参考文献
Balsamo, Aldo; Crotti, Paolo; Macchia, Bruno; Macchia, Franco; Martinelli, Adriano; et al.
Gazzetta Chimica Italiana, 1980 , vol. 110, # 5/6 p. 327 - 332
参考文献
Rupe; Steiger; Fiedler
Chemische Berichte, 1914 , vol. 47, p. 67
