(4-氨基-2-氯苯基)(苯基)甲酮合成路线 （共 6 条）
反应条件
thionyl chloride in N,N-dimethyl-formamide
参考文献
Zeneca Limited
Patent: US5821246 A1, 1998 ;
反应条件
tin(ll) chloride in ethanol
T=70°C; 2 h;
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
oxygen; potassium carbonate in water; dimethyl sulfoxide
Ambient temperature;
参考文献
Kulp, Stuart S.; McGee, Michael J.
Journal of Organic Chemistry, 1983 , vol. 48, # 22 p. 4097 - 4098
反应条件
1.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C
1.2: ZnCl2 / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
1.3: 84 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / 0 - 20 °C
2.1: 91 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C
View Scheme
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
1.1: SOCl2 / toluene; dimethylformamide / 2 h / Heating
2.1: n-BuLi / hexane; tetrahydrofuran / 0.33 h / -78 °C
2.2: ZnCl2 / tetrahydrofuran; hexane / 2 h / -78 - 20 °C
2.3: 84 percent / Pd(PPh3)4 / tetrahydrofuran; hexane / 0 - 20 °C
3.1: 91 percent / SnCl2*2H2O / ethanol / 2 h / 70 °C
View Scheme
参考文献
Ottosen, Erik Rytter; Sorensen, Morten Dahl; Bjoerkling, Fredrik; Skak-Nielsen, Tine; Fjording, Marianne Scheel; Aaes, Helle; Binderup, Lise
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5651 - 5662
反应条件
1: 96 percent / AlCl3
2: 85 percent / conc. HCl, Sn / propan-2-ol / 1 h / Heating
View Scheme
参考文献
Effenberger, Franz; Gutmann, Rainer
Chemische Berichte, 1982 , vol. 115, # 3 p. 1089 - 1102
