二甲基(氰基甲基)丙二酸酯合成路线 （共 6 条）
反应条件
1: malonic acid dimethyl ester With sodium hydride in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
2: alpha-bromoacetonitrile in tetrahydrofuran
T=20°C; 24 h; Inert atmosphere;
参考文献
Dsouza, Brendan R.; Lane, Timothy K.; Louie, Janis
Organic Letters, 2011 , vol. 13, # 11 p. 2936 - 2939
反应条件
sodium hydride in tetrahydrofuran
T=0 - 20°C;
参考文献
Garcia, Pierre; Moulin, Solenne; Mielo, Yves; Leboeuf, David; Gandon, Vincent; Aubert, Corinne; Malacria, Max
Chemistry - A European Journal, 2009 , vol. 15, # 9 p. 2129 - 2139
参考文献
McElvain; Mullineaux
Journal of the American Chemical Society, 1952 , vol. 74, p. 1811,1815
反应条件
2: aqueous hydrochloric acid
View Scheme
参考文献
McElvain; Mullineaux
Journal of the American Chemical Society, 1952 , vol. 74, p. 1811,1815
反应条件
1: aluminium methylate / 260 °C
3: aqueous hydrochloric acid
View Scheme
参考文献
McElvain; Mullineaux
Journal of the American Chemical Society, 1952 , vol. 74, p. 1811,1815
反应条件
(i), (ii) /BRN= 605396/, (iii) /BRN= 969135/; Multistep reaction;
参考文献
White,D.A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1976 , p. 1926 - 1930
