in tetrahydrofuran a cold (-20°C) soln. of the cuprate reagent was allowed to react with β-iodo enone in dry THF; the mixt. was stirred under dry Ar atm. at -20°C for 15 min and at room temp. for 30 min;; the slurry was filtered through a column of Florisil, which was eluted with diethyl ether; column chromy. on silica gel, elution with 1:9 mixt. of diethyl ether-petroleum ether, distn. (air-bath temp. 150-154°C/0.2 Torr); elem. anal.;

iodine; triethylamine; triphenylphosphine 4 h; Heating;

in tetrahydrofuran T=-78°C; 2 h;

1.) THF, -78 deg C, 1 h., ; -20 deg C, 1 h., ; 0 deg C, 1 h., 2.) neat, 180 deg C, 45 min.; Yield given. Multistep reaction;

(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate in ethylene glycol dimethyl ether T=100°C; Suzuki coupling; 14 h; Inert atmosphere;