6-甲氧基-N-甲基-3-吡啶胺合成路线 （共 3 条）
反应条件
CuSO4‵5H2O in water
T=100°C; 5 h;
参考文献
IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; KONDREDDI, Ravinder Reddy; LEONG, Seh Yong; MISHRA, Pranab Kumar; MOREAU, Robert Joseph; ROLAND, Jason Thomas; SIM, Wei Lin Sandra; SIMON, Oliver; TAN, Liying Jocelyn; YEUNG, Bryan KS; ZOU, Bin; BOLLU, Venkatataiah
Patent: WO2014/78802 A1, 2014 ;
Location in patent: Page/Page column 199; 200 ;
反应条件
1: 6-Methoxy-pyridin-3-ylamine With lithium diisopropyl amide in tetrahydrofuran
T=-78 - 20°C; Metallation; 1 h;
2: methyl iodide in tetrahydrofuran
T=-78 - 20°C; Alkylation;
参考文献
Zakrzewski, Peter; Gowan, Mathew; Trimble, Laird A.; Lau, Cheuk K.
Synthesis, 1999 , # 11 p. 1893 - 1902
反应条件
1: sodium methylate / 2 h / 75 °C
2: CuSO4‵5H2O / water / 5 h / 100 °C
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参考文献
IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; KONDREDDI, Ravinder Reddy; LEONG, Seh Yong; MISHRA, Pranab Kumar; MOREAU, Robert Joseph; ROLAND, Jason Thomas; SIM, Wei Lin Sandra; SIMON, Oliver; TAN, Liying Jocelyn; YEUNG, Bryan KS; ZOU, Bin; BOLLU, Venkatataiah
Patent: WO2014/78802 A1, 2014 ;
