5-氧代-2-氮杂双环[2.2.2]辛烷-2-羧酸叔丁酯合成路线 （共 8 条）
反应条件
dipyridinium dichromate in dichloromethane
参考文献
Gong, Leyi
Patent: US2004/176416 A1, 2004 ;
Location in patent: Page/Page column 8; 9; 10 ;
US 20040176416 A1
反应条件
1: 95 percent / SOCl2
2: 98 percent / H2 / Pd/C / ethyl acetate
3: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
4: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
5: 98 percent / LAH / tetrahydrofuran / Heating
6: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 98 percent / H2 / Pd/C / ethyl acetate
2: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
3: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
4: 98 percent / LAH / tetrahydrofuran / Heating
5: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 97 percent / BBr3 / CH2Cl2
2: 95 percent / SOCl2
3: 98 percent / H2 / Pd/C / ethyl acetate
4: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
5: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
6: 98 percent / LAH / tetrahydrofuran / Heating
7: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 58 percent / H2 / Rh/Al / acetic acid / 70 h / 58 °C / 2740.88 Torr
2: 80 percent / 1,3,5-trimethyl-benzene / 165 °C
3: 98 percent / LAH / tetrahydrofuran / Heating
4: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 98 percent / LAH / tetrahydrofuran / Heating
2: 96 percent / PDC / CH2Cl2
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
反应条件
1: 61 percent / tetrahydrofuran / 0 °C
2: 88 percent / H2 / PtO2 / ethyl acetate
3: 99 percent / TFA
View Scheme
参考文献
Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600
