1-二苯甲基-3-氟-氮杂环丁烷合成路线 （共 6 条）
反应条件
diethylamino-sulfur trifluoride
参考文献
Pfizer Inc
Patent: US2005/43292 A1, 2005 ;
Location in patent: Page/Page column 12 ;
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; acetonitrile 30 h; Heating / reflux;
参考文献
UCB, S.A.
Patent: WO2003/87064 A1, 2003 ;
Location in patent: Page/Page column 36 ;
WO 03/087064 A1
反应条件
[bis(2-methoxyethyl)amino]-sulfur trifluoride in dichloromethane T=-78 - 20°C;
参考文献
WO2004/43940 A1, ;
Page 50 ;
反应条件
1: With N-bromosuccinmide; triethylamine trihydrofluoride in dichloromethane T=20°C; 5 h; 2: With sodium tetrahydroborate in methanol 13 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 71, # 18 p. 7100 - 7102
反应条件
hydrogen; palladium(II) hydroxide/carbon in dichloromethane P=2068.65 Torr; 12 h;
参考文献
MERCK and CO., INC.
Patent: WO2005/116029 A1, 2005 ;
Location in patent: Page/Page column 53 ;
WO 2005/116029 A1
反应条件
hydrogenchloride in diethyl ether; ethyl acetate
Heating / reflux;
参考文献
Pfizer Inc
Patent: US2005/256310 A1, 2005 ;
Location in patent: Page/Page column 12 ;
