3,4,5-三甲氧基苯甲酸乙酯合成路线 （共 20 条）
反应条件
magnesium iodide 0.5 h; neat (no solvent);
参考文献
Bao, Kai; Fan, Aixue; Dai, Yi; Zhang, Liang; Zhang, Weige; Cheng, Maosheng; Yao, Xinsheng
Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5084 - 5090
反应条件
hydrazine hydrate in ethanol 6 h; Heating;
参考文献
Sung; Lee
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1101 - 1109
参考文献
Lawrence, Nicholas J.; Patterson, Richard P.; Ooi, Li-Ling; Cook, Darren; Ducki, Sylvie
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5844 - 5848
反应条件
1: With sodium diisobutyl-tert-butoxyaluminium hydride in tetrahydrofuran T=0°C; 4 h; Inert atmosphere; 2: With ammonia; iodine in tetrahydrofuran; water T=0 - 20°C; 3 h;
参考文献
Suzuki, Yusuke; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2011 , vol. 67, # 41 p. 7956 - 7962
反应条件
tetrahydrofuran; lithium aluminium tetrahydride
参考文献
Drake; Tuemmler
Journal of the American Chemical Society, 1955 , vol. 77, p. 1204,1207
反应条件
1: diethyl ether; aqueous hydrazine hydrate 2: pyridine View Scheme
参考文献
Nakata; Nishihara
Yakugaku Zasshi, 1944 , vol. 64, # 2 p. 74
Chem.Abstr., 1951 , p. 2955
反应条件
1: 89 percent / hydrazine hydrate / ethanol / 6 h / Heating 2: potassium hydroxide / ethanol / 3 h / 25 °C 3: hydrazine hydrate / H2O / 1 h / Heating 4: hydrazine hydrate / H2O / 1 h / Heating View Scheme
参考文献
Sung; Lee
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1101 - 1109
反应条件
1: 89 percent / hydrazine hydrate / ethanol / 6 h / Heating
2: potassium hydroxide / ethanol / 3 h / 25 °C
3: hydrazine hydrate / H2O / 1 h / Heating
4: hydrazine hydrate / H2O / 1 h / Heating
5: 96 percent / potassium carbonate / acetone / 10 h / Heating
6: 63 percent / aq. sodium hydroxide / 4 h / Heating
View Scheme
参考文献
Sung; Lee
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1101 - 1109
反应条件
1: H2NNH2*H2O / 6 h / Heating
2: ethanol / 4 h / Heating
3: 93 percent / aq. NaOH / 3 h / Heating
View Scheme
参考文献
Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.A.; Beshr, Eman A.M.; Ali, Taha F.S.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3839 - 3849
反应条件
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -30 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: Dowex-H / isopropyl alcohol / Reflux
View Scheme
参考文献
Verma, Alok K.; Singh, Himanshu; Satyanarayana, Mavurapu; Srivastava, Swayam P.; Tiwari, Priti; Singh, Amar B.; Dwivedi, Anil K.; Singh, Shio K.; Srivastava, Mukesh; Nath, Chandishwar; Raghubir, Ram; Srivastava, Arvind K.; Pratap, Ram
Journal of Medicinal Chemistry, 2012 , vol. 55, # 10 p. 4551 - 4567
