反应条件
1: 1.) n-BuLi / 1.) THF, hexane, a) -78 deg C, 30 min, b) 0 deg C 15 min, 2.) THF, hexane, a) -78 deg C, b) RT, 3 h
2: 65 percent / CBr4, Ph3P, pyridine / tetrahydrofuran / 4 h / Ambient temperature
View Scheme
参考文献
Kalgutkar, Amit S.; Kozak, Kevin R.; Crews, Brenda C.; Hochgesang Jr., G. Phillip; Marnett, Lawrence J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 24 p. 4800 - 4818
