N,N'-二甲基-1,2-环己二胺合成路线 （共 21 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Journal of the American Chemical Society, , vol. 106, # 19 p. 5754 - 5756
反应条件
1: aq. NaOH / benzene / 2 h / 25 °C 2: LAH / tetrahydrofuran / 14 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 52, # 44 p. 13837 - 13866
反应条件
ammonium chloride; methylamine
参考文献
Warner-Lambert Company
Patent: US4663343 A1, 1987 ;
US 4663343 A
反应条件
1: With L-(+)-tartaric acid in ethanol T=20°C; 1 h; RefluxResolution of racemate; 2: With potassium hydroxide in dichloromethane T=20°C; pH=9-10; RefluxResolution of racemate;
参考文献
Shen, Yan-Hong; Ye, Qing; Hou, Shao-Gang; Wang, Qun
Journal of Chemical Research, 2013 , vol. 37, # 4 p. 191 - 192
反应条件
1.1: water / 5 h / 80 °C / |Cooling with ice; |Sealed tube 2.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 6 h / 20 °C / |Cooling with ice 3.1: ammonium chloride / water / 5 h / 110 °C / |Sealed tube 4.1: L-(+)-tartaric acid / ethanol / 1 h / 20 °C / |Reflux; |Resolution of racemate 4.2: 20 °C / pH 9-10 / |Reflux; |Resolution of racemate View Scheme
参考文献
Journal of Chemical Research, , vol. 37, # 4 p. 191 - 192
反应条件
1.1: triphenylphosphine; diethylazodicarboxylate / dichloromethane / 6 h / 20 °C / |Cooling with ice 2.1: ammonium chloride / water / 5 h / 110 °C / |Sealed tube 3.1: L-(+)-tartaric acid / ethanol / 1 h / 20 °C / |Reflux; |Resolution of racemate 3.2: 20 °C / pH 9-10 / |Reflux; |Resolution of racemate View Scheme
参考文献
Journal of Chemical Research, , vol. 37, # 4 p. 191 - 192
反应条件
lithium aluminium tetrahydride; water 1) Et2O, 8 h, reflux; 2) Et2O; Multistep reaction;
参考文献
Helvetica Chimica Acta, , vol. 71, p. 1999 - 2021
反应条件
1: With L-(+)-tartaric acid in ethanol T=20°C; 1 h; RefluxResolution of racemate; 2: With potassium hydroxide in dichloromethane T=20°C; pH=9-10; RefluxResolution of racemate;
参考文献
Shen, Yan-Hong; Ye, Qing; Hou, Shao-Gang; Wang, Qun
Journal of Chemical Research, 2013 , vol. 37, # 4 p. 191 - 192
反应条件
1: With L-(+)-tartaric acid in ethanol T=20°C; 1 h; RefluxResolution of racemate; 2: With potassium hydroxide in dichloromethane T=20°C; pH=9-10; RefluxResolution of racemate;
参考文献
Shen, Yan-Hong; Ye, Qing; Hou, Shao-Gang; Wang, Qun
Journal of Chemical Research, 2013 , vol. 37, # 4 p. 191 - 192
反应条件
1: With L-(+)-tartaric acid in ethanol T=20°C; 1 h; RefluxResolution of racemate; 2: With potassium hydroxide in dichloromethane T=20°C; pH=9-10; RefluxResolution of racemate;
参考文献
Shen, Yan-Hong; Ye, Qing; Hou, Shao-Gang; Wang, Qun
Journal of Chemical Research, 2013 , vol. 37, # 4 p. 191 - 192
