4-氯-N,2-二羟基苯胺合成路线 （共 6 条）
反应条件
1: With thionyl chloride in tetrahydrofuran; 1,4-dioxane T=30°C; Inert atmosphere; 2: With triethylamine in 1,4-dioxane T=30°C; 3: With hydrogenchloride in 1,4-dioxane; water pH=2;
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
triethylamine in tetrahydrofuran
参考文献
American Cyanamid Company
Patent: US5484763 A1, 1996 ;
反应条件
1: carbonyldiimidazole / tetrahydrofuran / Heating 2: POCl3, Et3N / Heating View Scheme
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
反应条件
1: With hydroxylamine hydrochloride; sodium hydroxide in ethanol; water
T=20°C; 24 h; Cooling with iceInert atmosphere;
2: With hydrogenchloride
0.5 h; Reflux;
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
Location in patent: Page/Page column 12 ;
反应条件
hydroxylamine hydrochloride; sodium methylate in methanol
参考文献
American Cyanamid Company
Patent: US5484763 A1, 1996 ;
反应条件
1.1: sulfuric acid / ethanol; methanol / 24 h / Reflux
2.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 24 h / 20 °C / Cooling with ice; Inert atmosphere
2.2: 0.5 h / Reflux
View Scheme
参考文献
Jiangsu Guohua Investment Co., Ltd; Shanghai Institute of Pharmaceutical Industry
Patent: EP2322520 A1, 2011 ;
