反应条件
1: 2-piperidin-4-ylpyridinium N-oxide hydrochloride With potassium carbonate in 1,4-dioxane; toluene
T=20°C; 0.5 h;
2: formaldehyd; 3-methylbenzamide in 1,4-dioxane; toluene
T=80°C; 4 h;
参考文献
Patel, Meena V.; Kolasa, Teodozyj; Mortell, Kathleen; Matulenko, Mark A.; Hakeem, Ahmed A.; Rohde, Jeffrey J.; Nelson, Sherry L.; Cowart, Marlon D.; Nakane, Masaki; Miller, Loan N.; Uchic, Marie E.; Terranova, Marc A.; El-Kouhen, Odile F.; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Chang, Renjie; Martino, Brenda R.; Wetter, Jill M.; Marsh, Kennan C.; Martin, Ruth; Darbyshire, John F.; Gintant, Gary; Hsieh, Gin C.; Moreland, Robert B.; Sullivan, James P.; Brioni, Jorge D.; Stewart, Andrew O.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 25 p. 7450 - 7465