1: With sodium carbonate; palladium 10 on activated carbon in water; isopropyl alcohol
T=80°C; Suzuki Coupling;
2: With hydrogenchloride in water
pH=< 2;
参考文献
AMGEN INC
Patent: US2006/270724 A1, 2006 ;
Location in patent: Page/Page column 26 ;
US 20060270724 A1
tetrakis(triphenylphosphine) palladium(0); Davisil 500 Angstroem beads; sodium carbonate in water
Suzuki cross coupling reaction; 1.5 h; Heating;
参考文献
Lawson Daku, Kokovi M.; Newton, Roger F.; Pearce, Simon P.; Vile, Julia; Williams, Jonathan M. J.
Tetrahedron Letters, 2003 , vol. 44, # 27 p. 5095 - 5098
1: meta-carboxy iodo-benzene With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
T=0°C; 0.166667 h;
2: methanol With 4-(N,N-dimethlyamino)pyridine
参考文献
ELAN PHARMACEUTICALS, INC.
Patent: WO2005/87215 A1, 2005 ;
Location in patent: Page/Page column 245 ;
WO 2005/087215 A1
