4-羟基-3,5-二碘苯甲酸合成路线 （共 27 条）
反应条件
sulfuric acid T=65°C; 23 h;
参考文献
Chen, Li-Jun; Li, Quan-Jie; He, Jiuming; Tan, Hongwei; Abliz, Zeper; Yang, Hai-Bo
Journal of Organic Chemistry, 2012 , vol. 77, # 2 p. 1148 - 1153
反应条件
TiCl4 in methanol; diethyl ether
参考文献
Butera, John A.; Caufield, Craig E.; Graceffa, Russell F.; Greenfield, Alexander; Gundersen, Eric G.; Havran, Lisa Marie; Katz, Alan H.; Lennox, Joseph R.; Mayer, Scott C.; McDevitt, Robert E.
Patent: US6214877 B1, 2001 ;
参考文献
Frieden; Winzler
Journal of Biological Chemistry, 1949 , vol. 179, p. 423,425
反应条件
1: 4-hydroxy-3,5-diiodobenzoic acid With potassium carbonate in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Grimster, Neil P.; Connelly, Stephen; Baranczak, Aleksandra; Dong, Jiajia; Krasnova, Larissa B.; Sharpless, K. Barry; Powers, Evan T.; Wilson, Ian A.; Kelly, Jeffery W.
Journal of the American Chemical Society, 2013 , vol. 135, # 15 p. 5656 - 5668
反应条件
1: 92 percent / H2SO4 / Heating
2: 90 percent / K2CO3 / acetone / 16 h / Heating
View Scheme
参考文献
Zhou, Qin; Swager, Timothy M.
Journal of the American Chemical Society, 1995 , vol. 117, # 50 p. 12593 - 12602
参考文献
Wilkinson et al.
Biochemical Journal, 1951 , vol. 49, p. 714,715
参考文献
Samson; Santos
Univ. Phillipines Sci. Bl., 1934 , vol. 4, p. 149,153
