反应条件
1: 40 percent / trifluoromethane sulfonic acid; N-iodosuccinimide / 48 h / 20 °C
2: 100 percent / tin chloride; ethanol / tetrahydrofuran / 30 h / Heating
3: 91 percent / pyridine / CH2Cl2 / 0 - 20 °C
4: 83 percent / NaH / dimethylformamide / 2 h / 50 °C
5: 58 percent / Pd(PPh3)4 / dimethylformamide / 12 h / 85 °C
6: 93 percent / aq. NaOH / tetrahydrofuran; methanol / 12 h / 50 °C
View Scheme
参考文献
Stachel, Shawn J.; Coburn, Craig A.; Sankaranarayanan, Sethu; Price, Eric A.; Pietrak, Beth L.; Huang, Qian; Lineberger, Janet; Espeseth, Amy S.; Jin, Lixia; Ellis, Joan; Holloway, M. Katharine; Munshi, Sanjeev; Allison, Timothy; Hazuda, Daria; Simon, Adam J.; Graham, Samuel L.; Vacca, Joseph P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6147 - 6150
