1-[3-(三氟甲基)苯基]-1-丙醇合成路线 （共 13 条）
反应条件
hydrogen; platinum oxyde in ethanol T=20°C; P=750.06 Torr; 24 h;
参考文献
Goument, B.; Duhamel, L.; Mauge, R.
Bulletin de la Societe Chimique de France, 1993 , vol. 130, p. 459 - 466
反应条件
hydrogen; palladium on activated charcoal in ethanol T=70 - 75°C; 115 h;
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
hydrogen; palladium on activated charcoal in ethanol T=60°C; 24 h;
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
1: ethyl bromide With iodine; magnesium in diethyl ether Inert atmosphereReflux; 2: α,α,α-trifluoro-m-tolualdehyde in diethyl ether T=0°C; Inert atmosphere; 3: With water; ammonium chloride in diethyl ether T=0°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 12, # 10 p. 2214 - 2217
反应条件
1: 84 percent / 4 A molecular sieves, (S,S)-diisopropyl tartrate, titanium tetra iso-propoxide, tert-butyl hydroperoxide / CH2Cl2 / 113 h / -23 °C 2: 92 percent / hydrogen / 5 percent Pd/CaCO3 / ethanol / 115 h / Ambient temperature 3: 3 percent / hydrogen / 10 percent Pd/C / ethanol / 115 h / 70 - 75 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
1: 94 percent / hydrogen / 5 percent Pd/CaCO3 / ethanol / 115 h / Ambient temperature 2: 2 percent / hydrogen / 10 percent Pd/C / ethanol / 115 h / 70 - 75 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
反应条件
1: 92 percent / hydrogen / 5 percent Pd/CaCO3 / ethanol / 115 h / Ambient temperature 2: 3 percent / hydrogen / 10 percent Pd/C / ethanol / 115 h / 70 - 75 °C View Scheme
参考文献
Tetrahedron, , vol. 50, # 1 p. 171 - 188
参考文献
Journal of the American Chemical Society, , vol. 69, p. 2022
反应条件
1: p-trifluoromethylphenylboronic acid 2,2-dimethyl-1,3-propanediol ester With bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; cesium fluoride in 1,4-dioxane; toluene T=20°C; 0.5 h; Inert atmosphere; 2: propan-1-ol With chlorobenzene in 1,4-dioxane; toluene T=60°C; 1 h; Inert atmosphere;
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 31 p. 7022 - 7026
反应条件
1.1: magnesium sulfate / diethyl ether / 20 °C 2.1: bis(1,5-cyclooctadiene)nickel (0); Ipr.HCl; cesium fluoride / 1,4-dioxane; toluene / 0.5 h / 20 °C / Inert atmosphere 2.2: 1 h / 60 °C / Inert atmosphere View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 31 p. 7022 - 7026
