1,1,1-三氯-4-苯基-3-丁炔-2-醇合成路线 （共 13 条）
反应条件
1: phenylacetylene With triethylamine; zinc(II) chloride in toluene
T=25°C; 2 h;
2: chloral T=20°C;
参考文献
Si, Yu-Gui; Guo, Song-Po; Wang, Wan-Jun; Jiang, Biao
Journal of Organic Chemistry, 2005 , vol. 70, # 4 p. 1494 - 1496
反应条件
1: 2-hydroxy-2-methyl-4-phenyl-3-butyne With (o,o'-biphenylenedioxy)methylaluminium in hexane; dichloromethane
T=20°C; 0.5 h;
2: chloral in hexane; dichloromethane
T=20°C; Meerwein-Ponndorf-Verley alkynylation; 5 h;
参考文献
Ooi, Takashi; Miura, Tomoya; Ohmatsu, Kohsuke; Saito, Akira; Maruoka, Keiji
Organic and Biomolecular Chemistry, 2004 , vol. 2, # 22 p. 3312 - 3319
反应条件
1: GaCl3 / 18 h / 100 - 110 °C
2: methanol / 1 h / Heating
View Scheme
参考文献
Deleris; Dunogues; Babin; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 533 - 537
反应条件
hydrogenchloride in methanol
Heating;
参考文献
Calas,R. et al.
Journal of Organometallic Chemistry, 1974 , vol. 69, p. C15 - C17
反应条件
trichloroacetic acid sodium salt in N,N-dimethyl-formamide
T=0 - 20°C; 16 h; Inert atmosphere;
参考文献
Gupta, Manoj K.; Li, Zhexi; Snowden, Timothy S.
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4854 - 4860
反应条件
(o,o'-biphenylenedioxy)methylaluminium
1.) CH2Cl2, RT, 30 min, 2.) CH2Cl2, RT, 5 h; Yield given. Multistep reaction;
参考文献
Ooi; Miura; Maruoka
Journal of the American Chemical Society, 1998 , vol. 120, # 41 p. 10790 - 10791
反应条件
1: With Dess-Martin periodane
T=0 - 20°C; Inert atmosphere;
2: With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine
T=0 - 20°C; 10 h; Inert atmosphere;
参考文献
Gupta, Manoj K.; Li, Zhexi; Snowden, Timothy S.
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4854 - 4860
反应条件
1: Dess-Martin periodane / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere
2: trichloroacetic acid sodium salt / N,N-dimethyl-formamide / 16 h / 0 - 20 °C / Inert atmosphere
View Scheme
参考文献
Gupta, Manoj K.; Li, Zhexi; Snowden, Timothy S.
Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4854 - 4860
参考文献
Jozitsch
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1902 , vol. 34, p. 243
Bulletin de la Societe Chimique de France, 1903 , vol. <3> 30, p. 211
参考文献
Moureu; Desmots
Bulletin de la Societe Chimique de France, 1902 , vol. <3> 27, p. 369
