1,3-bis-(diphenylphosphino)propane; palladium diacetate in N,N-dimethyl-formamide T=60°C; 24 h; Inert atmosphere;

rhodium trichloride 3-hydrate in ethanol 12 h; Sealed tubeInert atmosphereReflux;

1: sodium cyanoborohydride / acetic acid / 10 - 25 °C / Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere 3: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere View Scheme

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere 2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere View Scheme

1: 4-(N,N-dimethlyamino)pyridine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide / dichloromethane / 0 - 25 °C / Inert atmosphere 2: sodium cyanoborohydride / acetic acid / 10 - 25 °C / Inert atmosphere 3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere 4: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 24 h / 60 °C / Inert atmosphere View Scheme