1-乙酰基-4-氰基-7-氮杂吲哚合成路线 (共 4 条)
反应条件
1: With water; sodium hydroxide in ethanol T=90°C; 16 h; 2: With hydrogenchloride in ethanol; water
参考文献
US2010/69381 A1, ;
Page/Page column 67 ;
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; copper (I) cyanide; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane
2 h; Heating / reflux;
参考文献
Amgen Inc.
Patent: US2003/225106 A1, 2003 ;
Location in patent: Page 95 ;
反应条件
Pd2dba3; CuCN in 1,4-dioxane; ethyl acetate
参考文献
Amgen Inc.
Patent: US6878714 B2, 2005 ;
US 6878714 B2
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) in 1,4-dioxane
2 h; Heating / reflux;
参考文献
AMGEN INC.
Patent: WO2006/12374 A1, 2006 ;
Location in patent: Page/Page column 215 ;
WO 2006/012374 A1