(1R,4S)-rel-4-(乙酰氨基)-2-环戊烯-1-羧酸甲酯合成路线 （共 12 条）
反应条件
1: 86 percent / H2O / toluene / 35 °C / pH 7, pig liver esterase (PLE) 2: 6 N aq. HCl / 4 h / Heating View Scheme
参考文献
Mekrami; Sicsic
Tetrahedron Asymmetry, 1992 , vol. 3, # 3 p. 431 - 436
反应条件
1: 86 percent / H2O / toluene / 35 °C / pH 7, pig liver esterase (PLE) 2: 6 N aq. HCl / 4 h / Heating View Scheme
参考文献
Mekrami; Sicsic
Tetrahedron Asymmetry, 1992 , vol. 3, # 3 p. 431 - 436
反应条件
1: 86 percent / H2O / toluene / 35 °C / pH 7, pig liver esterase (PLE) 2: 6 N aq. HCl / 4 h / Heating View Scheme
参考文献
Mekrami; Sicsic
Tetrahedron Asymmetry, 1992 , vol. 3, # 3 p. 431 - 436
反应条件
acetic acid
1 h; Heating;
参考文献
Handa, Sheetal; Earlam, George J.; Geary, Phillip J.; Hawes, John E.; Phillips, Gareth T.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 14 p. 1885 - 1886
反应条件
1: DCC / CH2Cl2
2: 1.) NH3, 2.) SOCl2, Na2CO3
3: 84 percent / AcOH / 1 h / Heating
View Scheme
参考文献
Handa, Sheetal; Earlam, George J.; Geary, Phillip J.; Hawes, John E.; Phillips, Gareth T.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 14 p. 1885 - 1886
反应条件
1: 1.) O3, 2.) AgO / 1.) -75 deg C, MeOH, 5 h, 2.) H2O, 0 deg C to 5 deg C
2: DCC / CH2Cl2
3: 1.) NH3, 2.) SOCl2, Na2CO3
4: 84 percent / AcOH / 1 h / Heating
View Scheme
参考文献
Handa, Sheetal; Earlam, George J.; Geary, Phillip J.; Hawes, John E.; Phillips, Gareth T.; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 14 p. 1885 - 1886
反应条件
pyridine
1 h; Ambient temperature; Yield given;
参考文献
Ikbal; Cerceau; Le Goffic; Sicsic
European Journal of Medicinal Chemistry, 1989 , vol. 24, # 4 p. 415 - 420
反应条件
1: 18 h / Heating
2: pyridine / 1 h / Ambient temperature
View Scheme
参考文献
Csuk, Rene; Doerr, Petra
Tetrahedron: Asymmetry, 1994 , vol. 5, # 2 p. 269 - 276
反应条件
1: 5percent aq. HCl / 24 h / Ambient temperature
2: 18 h / Heating
3: pyridine / 1 h / Ambient temperature
View Scheme
参考文献
Csuk, Rene; Doerr, Petra
Tetrahedron: Asymmetry, 1994 , vol. 5, # 2 p. 269 - 276
反应条件
pyridine
1 h; Ambient temperature; Yield given;
参考文献
Csuk, Rene; Doerr, Petra
Tetrahedron: Asymmetry, 1994 , vol. 5, # 2 p. 269 - 276
