(1S,4R)-4-氨基-2-环戊烯-1-羧酸盐酸盐(1:1)合成路线 （共 4 条）
反应条件
1.1: N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 3 h / 20 °C 1.2: pH 3 / |Acidic conditions 2.1: (R)-1-phenyl-ethyl-amine / hexane; chloroform / |Resolution of racemate View Scheme
参考文献
Rodriguez-Vazquez, Nuria; Salzinger, Stephan; Silva, Luis F.; Amorin, Manuel; Granja, Juan R.
European Journal of Organic Chemistry, 2013 , # 17 p. 3477 - 3493
反应条件
1.1: N-ethyl-N,N-diisopropylamine / water; 1,4-dioxane / 3 h / 20 °C 1.2: pH 3 / |Acidic conditions 2.1: (R)-1-phenyl-ethyl-amine / hexane; chloroform / |Resolution of racemate 3.1: palladium 10 on activated carbon; hydrogen / ethanol / 12 h View Scheme
参考文献
Rodriguez-Vazquez, Nuria; Salzinger, Stephan; Silva, Luis F.; Amorin, Manuel; Granja, Juan R.
European Journal of Organic Chemistry, 2013 , # 17 p. 3477 - 3493
反应条件
1: 98 percent / HCl / methanol / 1 h / Heating
2: 95 percent / Lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Kam, Bernard L.; Oppenheimer, Norman J.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3268 - 3272
反应条件
1: 98 percent / HCl / methanol / 1 h / Heating
2: 95 percent / Lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 °C
3: pyridine
View Scheme
参考文献
Kam, Bernard L.; Oppenheimer, Norman J.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3268 - 3272
