2-(3-甲酰基-4-羟基苯基)乙酸甲酯合成路线 （共 7 条）
反应条件
triethylamine; magnesium chloride in acetonitrile 3.5 h; Heating / reflux;
参考文献
Axys Pharmaceuticals, Inc.
Patent: US6867200 B1, 2005 ;
Location in patent: Page/Page column 80 ;
US 6867200 B1
反应条件
phosphoric acid in water T=20°C; Product distribution / selectivity;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2005/118554 A2, 2005 ;
Location in patent: Page/Page column 39 ;
反应条件
trifluoroacetic acid 2 h; Heating / reflux;
参考文献
EP1489078 A1, ;
Page 149-150 ;
EP 1489078 A1
反应条件
1: sulfuric acid / 0 - 80 °C 2: triethylamine; magnesium chloride / acetonitrile / |Inert atmosphere; |Reflux View Scheme
参考文献
WO2013/19682 A1, ;
WO 2013/019682 A1
反应条件
1.1: potassium carbonate; sodium iodide / acetonitrile / 3 h / 20 °C / Reflux 2.1: lithium hexamethyldisilazane / toluene / 1 h / 20 °C 2.2: 2.5 h / 20 °C 3.1: tetrabutyl-ammonium chloride; potassium carbonate / water; acetonitrile / 0.25 h / 20 °C 3.2: 24 h / 60 °C 4.1: sodium hydroxide / methanol; water / 3 h / 20 °C 4.2: 0.08 h View Scheme
参考文献
Bosch, Joan; Bachs, Jordi; Gomez, Antonia M.; Griera, Rosa; Ecija, Marta; Amat, Mercedes
Journal of Organic Chemistry, 2012 , vol. 77, # 14 p. 6340 - 6344
反应条件
sodium iodide in acetonitrile
3 h; Heating / reflux;
参考文献
URQUIMA S.A.
Patent: WO2006/10459 A1, 2006 ;
Location in patent: Page/Page column 11 ;
反应条件
1: N-bromosuccinmide / N,N-dimethyl-formamide / 4 h / 5 - 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 14 h / |Reflux
View Scheme
参考文献
NOVO NORDISK HEALTH CARE AG; GANDHI, Prafull S.; HENRIKSEN, Anette; ROSSMEISL, Charlotte C.; RASMUSSEN, Hanne Benedicte; ANDERSEN, Henrik Sune; BJØRN, Søren E.; NØRSKOV-LAURITSEN, Leif
Patent: WO2014/57068 A1, 2014 ;
