5-丁氧基-4'-氯-3-联苯乙酸合成路线 （共 5 条）
反应条件
1: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
2: POCl3, Na2CO3 / toluene
3: Na / toluene
4: (i) Br2, benzene, (ii) aq. NaOH, MeOH
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: POCl3, Na2CO3 / toluene
2: Na / toluene
3: (i) Br2, benzene, (ii) aq. NaOH, MeOH
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: Na / toluene
2: (i) Br2, benzene, (ii) aq. NaOH, MeOH
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. NaOH
2: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
3: POCl3, Na2CO3 / toluene
4: Na / toluene
5: (i) Br2, benzene, (ii) aq. NaOH, MeOH
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
(i) Br2, benzene, (ii) aq. NaOH, MeOH; Multistep reaction;
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
