4'-氯-5-甲氧基-3-联苯丙酸合成路线 （共 9 条）
反应条件
sulfuric acid in acetic acid
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
2: POCl3, Na2CO3 / toluene
3: Na / toluene
4: Br2 / benzene
5: LiAlH4 / diethyl ether
6: PBr3 / CCl4
7: ethanol
8: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: POCl3, Na2CO3 / toluene
2: Na / toluene
3: Br2 / benzene
4: LiAlH4 / diethyl ether
5: PBr3 / CCl4
6: ethanol
7: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: LiAlH4 / diethyl ether
2: PBr3 / CCl4
3: ethanol
4: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: Br2 / benzene
2: LiAlH4 / diethyl ether
3: PBr3 / CCl4
4: ethanol
5: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: Na / toluene
2: Br2 / benzene
3: LiAlH4 / diethyl ether
4: PBr3 / CCl4
5: ethanol
6: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: PBr3 / CCl4
2: ethanol
3: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: ethanol
2: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
反应条件
1: aq. NaOH
2: (i) NaOMe, MeOH, (ii) aq. NaOH, (iii) aq. HCl
3: POCl3, Na2CO3 / toluene
4: Na / toluene
5: Br2 / benzene
6: LiAlH4 / diethyl ether
7: PBr3 / CCl4
8: ethanol
9: aq. H2SO4 / acetic acid
View Scheme
参考文献
Tamura,Y. et al.
Journal of Medicinal Chemistry, 1977 , vol. 20, p. 709 - 714
