4-[4-氟-2-(苯基甲氧基)苯基]-5-甲酰基-2,6-双(1-甲基乙基)-3-吡啶羧酸甲酯合成路线 （共 6 条）
反应条件
1: tetrahydrofuran / 20 °C 2: LiAlH4 / tetrahydrofuran / 20 °C 3: PCC / CH2Cl2 / 20 °C View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
反应条件
1: 64 percent / pyridine / 1,2-dichloro-ethane / 0 °C
2: 92 percent / NH3 / methanol / 0 °C
3: 95 percent / K2CO3 / acetone / Heating
4: 78 percent / tetrahydrofuran / Heating
5: Red-Al<*> / tetrahydrofuran / 20 °C
6: PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
反应条件
1: 92 percent / NH3 / methanol / 0 °C
2: 95 percent / K2CO3 / acetone / Heating
3: 78 percent / tetrahydrofuran / Heating
4: Red-Al<*> / tetrahydrofuran / 20 °C
5: PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
反应条件
1: 78 percent / tetrahydrofuran / Heating
2: Red-Al<*> / tetrahydrofuran / 20 °C
3: PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
反应条件
1: 95 percent / K2CO3 / acetone / Heating
2: 78 percent / tetrahydrofuran / Heating
3: Red-Al<*> / tetrahydrofuran / 20 °C
4: PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
反应条件
1: Red-Al<*> / tetrahydrofuran / 20 °C
2: PCC / CH2Cl2 / 20 °C
View Scheme
参考文献
Ladouceur, Gaetan H.; Cook, James H.; Hertzog, Donald L.; Jones; Hundertmark, Thomas; Korpusik, Mary; Lease, Timothy G.; Livingston, James N.; MacDougall, Margit L.; Osterhout, Martin H.; Phelan, Kathleen; Romero, Romulo H.; Schoen, William R.; Shao, Chunning; Smith, Roger A.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 23 p. 3421 - 3424
