3-羟基-4-硝基苯甲酸合成路线 （共 58 条）
反应条件
1.1: sulfuric acid / 65 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere 3.1: sodium hydroxide / tetrahydrofuran; methanol; water / 12 h / 20 °C 3.2: Acidic conditions View Scheme
参考文献
Azzarito, Valeria; Prabhakaran, Panchami; Bartlett, Alice I.; Murphy, Natasha S.; Hardie, Michaele J.; Kilner, Colin A.; Edwards, Thomas A.; Warriner, Stuart L.; Wilson, Andrew J.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 32 p. 6469 - 6472
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 22 h / 25 - 30 °C / |Large scale 2: palladium 10 on activated carbon; hydrogen / 1,4-dioxane; methanol; water / 12 h / 35 - 40 °C View Scheme
参考文献
Ishikawa, Minoru; Tsushima, Masaki; Kubota, Dai; Yanagisawa, Yumiko; Hiraiwa, Yukiko; Kojima, Yasuo; Ajito, Keiichi; Anzai, Naomichi
Organic Process Research and Development, 2008 , vol. 12, # 4 p. 596 - 602
反应条件
1: boric acid trimethyl ester; boron trifluoride diethyl etherate; borane-pyridine complex; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 3 h / 20 °C 2: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C View Scheme
参考文献
Palakollu, Veerabhadraiah; Kanvah, Sriram
Journal of Photochemistry and Photobiology A: Chemistry, 2014 , vol. 281, p. 18 - 26
反应条件
1: durch Methylierung 2: ferrohydroxide; alkali View Scheme
参考文献
Simonsen; Rau
Journal of the Chemical Society, 1917 , vol. 111, p. 232
反应条件
hydrogenchloride; tin
参考文献
Kasuya; Igarashi; Fukui
Journal of Pharmaceutical Sciences, 1987 , vol. 76, # 4 p. 303 - 305
反应条件
sulfuric acid 2 h; Heating;
参考文献
UNIVERSITY OF LJUBLJANA; LEK PHARMACEUTICALS d.d.
Patent: WO2005/51934 A1, 2005 ;
Location in patent: Page/Page column 43-45 ;
反应条件
1: 87 percent / 10 M BH3*SMe2 / tetrahydrofuran / 3 h / Heating 2: 100 percent / MnO2 / CH2Cl2 / 20 h View Scheme
参考文献
Olszewski; Marshalla; Sabat; Sundberg
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4285 - 4296
反应条件
1: 70 percent / conc. H2SO4 / Heating 2: 98 percent / H2 / Pd/C / ethanol / 6 h View Scheme
参考文献
Einhorn; Pfyl
Justus Liebigs Annalen der Chemie, 1900 , vol. 311, p. 55
反应条件
borane-pyridine complex; boric acid trimethyl ester; boron trifluoride diethyl etherate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride T=20°C; 3 h;
参考文献
Palakollu, Veerabhadraiah; Kanvah, Sriram
Journal of Photochemistry and Photobiology A: Chemistry, 2014 , vol. 281, p. 18 - 26
反应条件
hydrogenchloride in methanol; 1,2-dichloro-ethane
参考文献
The Procter and Gamble Company
Patent: US2005/5370 A1, 2005 ;
