反应条件
1: 1.) NaH / 1.) ethyl ether, reflux, 2.) ethyl ether, RT, 6 h 2: aq. KOH / ethanol / 24 h / Heating 3: dimethylformamide / 4 h / 100 - 110 °C 4: HCl / 24 h / Ambient temperature 5: 100 percent / H2 / 5percent Pd/C / methanol / Ambient temperature 6: 0.42 g 7: 0.1 M potassium phosphate buffer (pH 7.8) / 24 h / Ambient temperature; horse liver esterase 8: iodine monochloride, 6percent aq. HCl / 1 h / 70 °C View Scheme
参考文献
Colombo, M.; Amici, M. De; Micheli, C. De; Pitre, D.; Carrea, G.; Riva, S.
Tetrahedron: Asymmetry, 1991 , vol. 2, # 10 p. 1021 - 1030
