反应条件
1: palladium dichloride; triphenylphosphine; copper(l) iodide; diethylamine / ethyl acetate / 4 h / 50 °C / |Large scale 2: hydrogen; 5 palladium on charcoal / dichloromethane / 3.5 h / 3345.86 Torr / |Inert atmosphere; |Autoclave; |Large scale 3: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; potassium bromide; sodium hypochlorite; sodium hydrogencarbonate / dichloromethane; water / -10 - 20 °C / pH 9.5 / |Large scale 4: DBBA; hydrogen bromide; acetic acid / dichloromethane / 25 °C / |Large scale 5: sodium acetate / water; acetonitrile / 3 h / 40 °C / |Large scale 6: sodium hydroxide / water / 1.5 h / 40 °C / |Large scale 7: 2-chloro-4,6-dimethoxy-[1,3,5]triazine; 4-methylmorpholine N-oxide / N,N-dimethyl-formamide / 1.5 h / 25 °C / |Large scale View Scheme
参考文献
BERLIN-CHEMIE AG; BONACCORSI, Fabrizio; CALVANI, Federico; PASQUI, Franco
Patent: WO2014/24164 A1, 2014 ;
