反应条件
1.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / acetonitrile / 0.5 h / 20 °C / |Inert atmosphere
1.2: 18 h / 20 - 100 °C / |Inert atmosphere; |Sealed tube
2.1: sodium hydroxide / ethanol / 18 h / 20 °C
3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C
3.2: 18 h / 20 °C
4.1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 3 h / 20 °C / |Inert atmosphere
5.1: tetrahydrofuran; acetic acid / 0.08 h / 20 °C / |Inert atmosphere
5.2: 4 h / 20 °C / |Inert atmosphere
6.1: hydroxylamine; potassium cyanide / tetrahydrofuran; methanol; water / 18 h / 20 °C
View Scheme
参考文献
Hale, Michael R.; Hill, Pamela; Lahiri, Sushmita; Miller, Matthew D.; Ross, Philip; Alm, Richard; Gao, Ning; Kutschke, Amy; Johnstone, Michele; Prince, Bryan; Thresher, Jason; Yang, Wei
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 8 p. 2362 - 2367
