反应条件
1: 89 percent / Br2, triethylamine / acetic acid / 0.5 h / Heating
2: 1.) methanesulfonic acid, NaNO2, 2.) aq. sodium azide / 1.) H2O, 5 deg C, 24 h, 2.) H2O, 5 deg C
3: 89 percent / KOH / methanol / 1 h / Ambient temperature
4: thionyl chloride / 5 h / Heating
5: 95 percent / pyridine / CH2Cl2 / Ambient temperature
6: 51 percent / BF3*Et2O / CH2Cl2 / 1.) -78 deg C, 1 h, 2.) RT, overnight
7: 5 mg / H2, triethylamine / 10percent Pd/C / 2 h / Ambient temperature
8: 71 percent / NaHCO3 / CHCl3 / 0.33 h
View Scheme
参考文献
Costa, Brian R. de; Lewin, Anita; Schoenheimer, Joyce A.; Skolnick, Phil; Rice, Kenner C.
Heterocycles, 1991 , vol. 32, # 12 p. 2343 - 2355
