N,1-二甲基-1H-吲哚-2-羧酰胺合成路线 （共 10 条）
反应条件
sodium hydroxide; LiAlH4 in tetrahydrofuran; methanol; water
参考文献
Affinium Pharmaceuticals, Inc.
Patent: US6762201 B1, 2004 ;
Location in patent: Page/Page column 13 ;
反应条件
sodium hydroxide; LiAlH4 in tetrahydrofuran; methanol; water
参考文献
Brandt, Martin; Dewolf JR., Walter E.; Keller, Paul M.; Patel, Arunbhai H.; Payne, David J.; Reed, Shannon L.; Seefeld, Mark A.; Tew, David G.; Wallis, Nicola G.; West, Joshua M.
Patent: US2004/53814 A1, 2004 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
SmithKline Beecham Corporation
Patent: US5977101 A1, 1999 ;
反应条件
in methanol; water
T=20°C; 120 h;
参考文献
Affinium Pharmaceuticals, Inc.
Patent: US6762201 B1, 2004 ;
Location in patent: Page/Page column 12;13 ;
反应条件
NaH in tetrahydrofuran; water; N,N-dimethyl-formamide; methylamine
参考文献
SmithKline Beecham Corporation
Patent: US6503903 B1, 2003 ;
反应条件
in 1,4-dioxane; diethyl ether; water
3 h; Ambient temperature;
参考文献
Cruces; Elorriaga; Fernandez Alvarez; Lopez Chico; Nieto Lopez
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 7-8 p. 567 - 573
参考文献
SmithKline Beecham Corporation
Patent: US5977101 A1, 1999 ;
反应条件
1: methanol. HCl
2: methanol
View Scheme
参考文献
Johnson et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 423,428
Journal of the American Chemical Society, 1947 , vol. 69, p. 2370
参考文献
Johnson et al.
Journal of the American Chemical Society, 1945 , vol. 67, p. 423,428
Journal of the American Chemical Society, 1947 , vol. 69, p. 2370
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in acetonitrile
0.0833333 h; Inert atmosphere;
2: With triethylamine in acetonitrile
1.5 h; Inert atmosphere;
参考文献
Hyster, Todd K.; Rovis, Tomislav
Journal of the American Chemical Society, 2010 , vol. 132, # 30 p. 10565 - 10569
