2-甲基-6-硝基苯甲酸甲酯合成路线 （共 14 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane T=80°C; 16 h;
参考文献
Deshpande, Girish Nilkanth; Weipert, Paul David; Ensley, Michael W.
Patent: US2011/251395 A1, 2011 ;
Location in patent: Page/Page column 15 ;
反应条件
in tetrachloromethane; ethyl acetate
参考文献
Shah, Jamshed H.; Conner, Barry P.; Swartz, Glenn M.; Hunsucker, Kimberly A.; Rougas, John; D'Amato, Robert J.; Pribluda, Victor; Treston, Anthony
Patent: US2003/139451 A1, 2003 ;
反应条件
1.1: dibenzoyl peroxide; N-bromosuccinmide / 1,2-dichloro-ethane / 8 h / Reflux 2.1: ethanol; tetrahydrofuran / 2 h 3.1: hydrogen / 5 palladium on charcoal / dichloromethane; ethanol / 2068.65 Torr 4.1: N-bromosuccinmide / dichloromethane / 1 h / -10 - -8 °C 4.2: 0.33 h View Scheme
参考文献
WO2012/74951 A1, ;
WO 2012/074951 A1
反应条件
1: 72 percent / N-bromosuccinimide / CCl4 / 7 h / Heating
2: 75 percent / pyridine / ethanol / 48 h / Heating
3: H2 / Pd/C / ethyl acetate / 3 h
View Scheme
参考文献
Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 9 p. 1098 - 1102
