2-氯-4-(氯磺酰基)苯甲酸合成路线 （共 4 条）
反应条件
sodium hydroxide; chloroacetic acid
参考文献
ICI Americas Inc.
Patent: US5008448 A1, 1991 ;
反应条件
1: With hydrogenchloride; sodium nitrite in water; acetic acid
T=-10 - -5°C; 1 h;
2: With sulfur dioxide; copper(l) chloride in acetic acid
T=0 - 10°C; 0.5 h;
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
Location in patent: Paragraph 0162; 0188 ;
反应条件
1.1: iron; ammonium chloride / water; ethanol / 2 h / |Reflux
2.1: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / -10 - -5 °C
2.2: 0.5 h / 0 - 10 °C
View Scheme
参考文献
Genetech, Inc.; Curis, Inc.; Cai, Xiong; Qian, Changgeng; Zhai, Haixiao
Patent: US2014/18368 A1, 2014 ;
参考文献
Farbenfabr.Bayer
Patent: DE960197 , 1954 ;
