1: With phenyl silane; triethylamine in tetrahydrofuran T=20°C; 2 h; Inert atmosphere; 2: With water 0.25 h; Inert atmosphere;

1: 5-(4-methoxy-benzyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione With potassium hydride in acetonitrile T=20°C; 0.333333 h; Inert atmosphereGlovebox; 2: 4-acetylamino-2,2,6,6-tetramethylpiperidine-1-oxoammonium in acetonitrile T=24.84°C; Inert atmosphereGlovebox; Thermodynamic data;

sodium tetrahydroborate; acetic acid in dichloromethane T=0 - 20°C; Inert atmosphere;

2,6-dimethyl-1,4-dihydropyrimidine-3,5-dicarboxylic acid diethyl ester; L-proline in ethanol T=25°C; Knoevenagel/hydrogenation reaction;

1: potassium phosphate / ethanol 2: NaBH4 / ethanol View Scheme

1: potassium phosphate / ethanol 2: NaBH4 / ethanol View Scheme

1: potassium carbonate / N,N-dimethyl-formamide / 18 h / |Reflux 2: piperidine / ethanol / 20 °C 3: acetic acid; sodium tetrahydroborate / dichloromethane / 1 h / 0 - 20 °C View Scheme