1: 2-(2-tert-butoxycarbonylamino-pyridin-4-yl)-1-(3-methylphenyl)ethanone With bromine in acetic acid T=20°C; 0.5 h; 2: ethanethioamide in N,N-dimethyl-formamide T=20°C; 20 h; 3: With hydrogenchloride in water T=100°C; 1 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1180518 A1, 2002 ;
Location in patent: Referential example 17 ;
1: With sodium hydrogencarbonate in tetrahydrofuran T=0°C; 2: With trifluoroacetic anhydride in tetrahydrofuran T=0 - 20°C; 1 h; 3: With pyridine in tetrahydrofuran T=0 - 20°C; 3 h;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1186604 A1, 2002 ;
Location in patent: Page 110 ;
EP 1186604 A1
