反应条件
1: 2-amino-2-methylpropionic acid With N,O-bis(trimethylsilyl) trifluoroacetamide in acetonitrile
3.5 h; Reflux;
2: 5-chloro-2-thiophenecarbonyl chloride With triethylamine in acetonitrile
0.25 h; Reflux;
参考文献
Priepke, Henning; Dahmann, Georg; Gerlach, Kai; Pfau, Roland; Wienen, Wolfgang; Schuler-Metz, Annette; Handschuh, Sandra; Nar, Herbert
Patent: US2010/216769 A1, 2010 ;
Location in patent: Page/Page column 19 ;