反应条件
1.1: tetrahydrofuran / 4 h / -25 °C
1.2: 94 percent / hydrochloric acid / tetrahydrofuran / 0.17 h / 20 °C
2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
3.1: pyridine / 20 °C
4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C
5.1: 93 percent / hydrogen / Pd/C / methanol / 0.17 h / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Takahata, Sho; Iida, Maiko; Atsumi, Kunio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1106 - 1116
