反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 90 - 95 °C 2: thionyl chloride / dichloromethane / 2 h / 20 °C 3: 16 h / 130 °C 4: potassium tert-butylate / tetrahydrofuran 5: hydrogenchloride; water / 1,4-dioxane 6: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C View Scheme
参考文献
Johnson, Douglas S.; Stiff, Cory; Lazerwith, Scott E.; Kesten, Suzanne R.; Fay, Lorraine K.; Morris, Mark; Beidler, David; Liimatta, Marya B.; Smith, Sarah E.; Dudley, David T.; Sadagopan, Nalini; Bhattachar, Shobha N.; Kesten, Stephen J.; Nomanbhoy, Tyzoon K.; Cravatt, Benjamin F.; Ahn, Kay
ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 2 p. 91 - 96